Rich said: So, I have not seen any issues arise from supplementing with DIM. In general it is not believed to have goitrogenic effects (those are different compounds). I am still usually cautious in using it, meaning monitoring it mainly by tracking symptoms if someone is hypothyroid, but in general you can use it. So for instance someone with hormonal imbalances that wants to use DIM but has a borderline hypothyroid condition - you can use it but just watch how it all goes just in case. For the consumption of cruciferous vegetables I would be much more cautious - they should be a minor part of the diet rather than a significant part. And broccoli and cabbage are better choices, and always cooked, than Brussel sprouts and kale, which are the highest in goitrogens. Overall though it all depends on the individual - if it is subclinical as you say, you might be able to get away with it if you take care of the thyroid function in other ways. With the thyroid it is all about monitoring and adjusting your protocol as you go depending on response.