I was reviewing the St. John's Wort materia medica sheet and the note about its efficacy for "hepatic or GI-induced depression" caught my attention. I've always been curious about the gut-brain connection and would love to know how/why St. John's is especially indicated here. I've often wondered if GI upset causes anxiety-like symptoms (or sensations that resemble anxiety), knowing that of course anxiety can create GI issues. Depression connections though (aside from the synthesis of serotonin in the gut and the importance of diet for mental health) I'm less familiar with. Also curious if you speak more about GI-induced anx/depression in this or the grad course? Thank you!

This is not based on research it is based on traditional use and my clinical experience. Yes, GI upset can cause anxiety and anxiety can cause Gi upset. Studies clearly show that a disordered gut and gut dysbiosis can cause or worsen depression. We will have a class on this topic in the next 6 months.