1. it depends on the level of tannins, Uva Ursi had moderate tannin levels, while Oak bark has very high levels of tannins, so long term for Uva -ursi is weeks while Oak bark it might be a few days.
2. Tannins can interfere with mineral absorption (especially iron) and alkaloidal medications, worsen or cause yin deficiency (dryness), constipation and gastric irritation.
3. I never use Uva- Ursi long term, i.e. more than a few weeks, there are better herbs for UTI’s. Yes, you can combine Uva-Ursi with other herbs but depending on what and who you are treating, the other herbs will change. Uva-ursi tends too cause gastric upset and turns the urine a greenish color (not a health problem, but many people feel uncomfortable with this)