Rich said: I can't really give health advice that will always be true in all cases, and ultimately it is a personal choice as well whether someone would take a particular medication or not. There are holistic MDs who use statins but in a very targeted way when they are more warranted. The evidence post-MI is much stronger for efficacy than prevention of a first MI, in addition to the evidence of efficacy being stronger for men than for women. So yes there are herbs that can be used but it would not be right to think of it as "what herbs can I use instead of statins?" As you study herbal medicine you'll learn how important reframing is. This is what David is referring to when he says there is a lot of use of medicinal herbs but not a lot of herbal medicine. The goal of the herbalist should not be to lower someone's LDL; the goal of the herbalist should be to help the person prevent a heart attack or stroke, which may or may not include an effect on LDL levels. Because this is a real person you are referring to, not an abstract question, really what needs to happen is a full consultation with a practitioner to determine what they can do. The fact that they may be suffering serious adverse effects from the statins is enough to explore alternatives for sure.